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Measurement of intrinsic membrane properties. A: representative I-V steps under current-clamp mode. Time constant (tau) was determined using the following equation: V = −ΔV × e−t/tau. B: single I-V step under voltage-clamp mode. Rin = 50 mV/I(Ins). Membrane capacitance (C) = tau/Rin. Normalized rebound current (or Ih current) = I(Rebound) [or Ih]/C. AP, action potential; Amp, amplitude; Thr, threshold; I(ins), instantaneous current.
