Figure 2.

Impact of IPO13 polymorphism rs2428953 on airway hyperresponsiveness. Mean log(methacholine PC₂₀) values and SEM. Common genotype (CC) denoted by solid black lines, heterozygotes and TT homozygotes denoted by dashed red lines. Open circles denote placebo/nedocromil groups, closed circles represent budesonide groups. Vertical line at 0 months denotes time of randomization. Airway hyperresponsiveness was significantly different (p < 0.05) between the placebo/nedocromil subjects with CC genotype and all other subjects at all time points following randomization, as denoted by (*).