Table 3.

Impact of IPO13 polymorphisms on methacholine hyperresponsiveness (PC₂₀) in childhood asthma

				Treatment-stratified analysis
SNP	Genic location	MAF	All subjects (n = 654)	Budesonide (n = 214)	Placebo or Nedocramil (n = 440)
rs6671164	5' genomic	0.223	0.002	-	0.004
rs4448553	5' genomic	0.223	0.02	-	0.01
rs1990150	Intron 1	0.148	0.02	-	0.04
rs2240447	Exon 2	0.224	-	-	-
rs2486014	Intron 2	0.097	0.04	-	-
rs2301993	Intron 12	0.222	0.002	-	0.001
rs2301992	Intron 13	0.049	0.02	-	0.03
rs1636879	Intron 14	0.102	0.02	-	0.04
rs7412307	3' genomic	0.184	0.02	-	0.04
rs2428953	3' genomic	0.11	0.002	-	0.005

Results based on repeated-measures analysis assuming an additive genetic model with log₁₀-PC₂₀. All analyses are adjusted for PC20 prior to treatment randomization, age, gender, height, study center and study visit. All-subject analysis adjusted for treatment-arm assignment (budesonide vs. other). MAF = minor allele frequency. "-" denotes nominal p-value > 0.05.