Table 4.

Relative risks of stroke by quintiles of aMED.

	Q1	Q2	Q3	Q4	Q5	P trend
TOTAL Stroke
Cases	341	380	370	341	331
Person years	271,209	285,181	276,345	274,812	293,382
Age & energy adjusted	1	0.91 (0.79-1.06)	0.88 (0.76-1.03)	0.75 (0.64-0.88)	0.65 (0.55-0.77)	<0.0001
Multivariate adjusted *	1	1.00 (0.86-1.16)	1.03 (0.89-1.20)	0.92 (0.79-1.08)	0.87 (0.73-1.02)	0.03
Ischemic†
Cases	163	210	209	188	189
Age & energy adjusted	1	1.04 (0.85-1.28)	1.01 (0.82-1.25)	0.84 (0.67-1.04)	0.74 (0.59-0.92)	0.0004
Multivariate adjusted *	1	1.12 (0.91-1.40)	1.13 (0.91-1.40)	0.98 (0.79-1.23)	0.94 (0.74-1.18)	0.24
Hemorrhagic†
Cases	71	74	71	56	57
Age & energy adjusted	1	0.89 (0.64-1.24)	0.87 (0.62-1.22)	0.64 (0.45-0.92)	0.60 (0.41-0.87)	0.002
Multivariate adjusted *	1	0.99 (0.71-1.37)	1.01 (0.72-1.42)	0.77 (0.55-1.15)	0.79 (0.54-1.16)	0.17
Non-fatal
Cases	283	317	305	282	293
Age & energy adjusted	1	0.92 (0.78-1.08)	0.88 (0.74-1.03)	0.75 (0.63-0.89)	0.69 (0.58-0.82)	<0.0001
Multivariate adjusted *	1	1.00 (0.85-1.17)	1.00 (0.85-1.19)	0.90 (0.75-1.07)	0.90 (0.75-1.08)	0.12
Fatal
Cases	58	63	65	59	38
Age & energy adjusted	1	0.88 (0.62-1.27)	0.91 (0.64-1.31)	0.77 (0.53-1.12)	0.46 (0.30-0.71)	0.0001
Multivariate adjusted *	1	1.04 (0.72-1.49)	1.17 (0.81-1.68)	1.07 (0.73-1.58)	0.69 (0.44-1.07)	0.10

^*adjusted for the same variables as in table 2.

^†Strokes that could not be clearly classified as ischemic or hemorrhagic were included in the analysis of total stroke but not in ischemic or hemorrhagic strokes.