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Top 30 TFBSs selected by RF and their mean decrease in accuracy in up- vs. down-regulated SAMD target genes. The mean decrease in accuracy was an average of 100 runs of RF. Experimentally known SMAD interacting TFBSs are marked with ☼. Statistically significant (p-value < 0.05 by Fisher's exact test) over-represented TFBSs are labeled in red and blue colors: red, over-represented in up- compared to down-regulated; Blue, over-represented in down- compared with up-regulated genes.
