Table 1.

Randomised controlled trials (RCTs) assessing the usefulness of aripiprazole in bipolar disorder

							Patients (n)
Trial no.	Publication	Target	Duration	Comparator	Placebo	Add on	Agent	Comparator	Placebo	Comments
CN138-009	Keck et al., 2003 [68]	Mania	3 weeks	No	Yes	No	130		132	Agent > placebo
CN138-074/NCT00036101	Sachs et al., 2006 [69]	Mania	3 weeks	No	Yes	No	137		135	Agent > placebo
CN138-135/NCT00095511	Keck et al., 2009 [70]	Mania	12 weeks	Lithium	Yes	No	155	160	165	Agent = comparator > placebo
CN138-162/NCT00097266	Young et al., 2009 [71]	Mania	12 weeks	Haloperidol	Yes	No	167	165	153	Agent = comparator > placebo
CN138-007	unpublished	Mania	3 weeks	No	Yes	No	267		134	Agent = placebo
CN138-013	Zimbroff et al., 2007 [74]	Mania	24 h	Lorazepam	Yes	No	156	70	75	Agent = comparator > placebo
CN138-077/NCT00046384	Unpublished	Mania	3 weeks	No	Yes	No	29		27	No results
CN138008	Vieta et al., 2005 [72]	Mania	12 weeks	Haloperidol	No	No	175	172		Agent > comparator
CN138-134/NCT00257972	Vieta et al., 2008 [73]	Mania	6 weeks	No	Yes	Lithium/Vpx	253		131	Agent > placebo
CN138-096/NCT00080314	Thase et al., 2008 [75]	Bipolar depression	8 weeks	No	Yes	No	186		188	Agent = placebo
CN138-146/NCT00094432	Thase et al., 2008 [75]	Bipolar depression	8 weeks	No	Yes	No	187		188	Agent = placebo
CN138-010/NCT00036348	Keck et al., 2006/7 [76,77]; Muzina et al., 2008 [78]	Maintenance	26 to 100 weeks	No	Yes	No	77		83	Agent > placebo
CN138008	Unpublished	Maintenance	14 weeks	Haloperidol	No	No	30	9		No results
CN138-135/NCT00095511	Unpublished	Maintenance	40 weeks	Lithium	No	No	56	38		Agent = comparator

Vpx: Valproex