Box 2.

Disease States Associated With Increased Lysozyme Levels

Malignancy

Leukemia: particularly CMML, CMoL

Multiple myeloma

Hodgkin disease

Carcinoma: particularly stomach

Hemodynamic compromise

Acute tubular necrosis

Perforated peptic ulcer

Severe congestive heart failure

Myocardial infarction

Severe pneumonia

Miscellaneous

Cadmium poisoning

Sarcoidosis

Typhoid fever

Renal tubular acidosis

Amyloidosis

Note: Increased lysozyme levels: urine lysozyme greater than 1.9 µg/mL, serum lysozyme greater than 14 µg/mL.

Abbreviations: CMML, chronic myelomonocytic leukemia; CMoL, chronic monocytic leukemia.