Table 2. Odds ratio (OR) including 95% confidence intervals (CI) for 5HT2A rs6311 (dominant effect of the A allele, AA & AG vs GG), 5HT2C rs3813929 (effect of the T vs C alleles) and COMT rs4680 (recessive effect of the G allele, GG vs GA & AA) in relation to obesity phenotypes.
| 5HT2A | 5HT2C | COMT | ||||
| -1438G/A | -759C/T | 24938A/G | ||||
| Obesity phenotypes | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P |
| S-46 (n = 1570) | ||||||
| BMI (kg/m2)1 | 1.01 [0.97; 1.04] | 0.70 | 1.02 [0.97; 1.07] | 0.40 | 1.03 [0.99;1.08] | 0.13 |
| Fat-BMI (kg/m2)1 | 0.99 [0.93; 1.05] | 0.73 | 1.04 [0.96; 1.12] | 0.31 | 1.08 [1.01; 1.16] | 0.03 |
| Waist (cm)2 | 1.00 [0.97; 1.04] | 0.81 | 1.03 [0.98; 1.07] | 0.29 | 1.04 [1.00; 1.09] | 0.06 |
| S-49* (n = 551) | ||||||
| BMI (kg/m2)1 | 1.00 [0.95; 1.06] | 0.99 | 1.03 [0.96; 1.11] | 0.41 | 1.03 [0.96; 1.10] | 0.47 |
| Fat-BMI (kg/m2)1 | 1.01 [0.93; 1.10] | 0.82 | 1.07 [0.95; 1.20] | 0.25 | 1.04 [0.94; 1.16] | 0.43 |
| Waist (cm)2 | 1.01 [0.95; 1.03] | 0.80 | 1.04 [0.97; 1.12] | 0.26 | 1.02 [0.95; 1.09] | 0.55 |
BMI = body mass index, fat-BMI = fat body mass index.
1
Per two-unit increment of BMI or fat-BMI.
2
Per five cm increment of waist circumference.