Table 3. Odds ratio (OR) including 95% confidence intervals (CI) for 5HT2A rs6311 (dominant effect of the A allele, AA & AG vs GG), 5HT2C rs3813929 (effect of the T vs C alleles) and COMT rs4680 (recessive effect of the G allele, GG vs GA & AA) in relation to metabolic quantitative traits.

	5HT2A		5HT2C		COMT
	-1438G/A		-759C/T		24938A/G
Metabolic traits	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
S-46 (n = 1570)
p-glucose (10 mmol/L)	0.98 [0.94; 1.02]	0.38	1.01 [0.96; 1.07]	0.61	1.04 [1.00; 1.09]	0.05
s-Cholesterol (10 mmol/L)	2.66 [1.11; 6.40]	0.03	1.64 [0.54; 4.98]	0.38	1.23 [0.44; 3.49]	0.69
s-HDL (mmol/L)	0.88 [0.66; 1.16]	0.36	0.86 [0.59; 1.25]	0.43	0.79 [0.56; 1.12]	0.18
Systolic BP (10 mmHg)	0.97 [0.91; 1.03]	0.31	1.00 [0.92; 1.08]	0.93	0.98 [0.90; 1.05]	0.48
S-49 (n = 551) 1
p-glucose (10 mmol/L)	1.74 [0.50; 6.09]	0.38	4.56 [1.13; 18.4]	0.03	0.75 [0.13; 4.32]	0.75
p-insulin (50 pmol/L)	1.13 [0.91; 1.39]	0.27	0.73 [0.51; 1.06]	0.10	1.05 [0.81; 1.37]	0.72
BIGTT-SI	0.94 [0.77; 1.15]	0.55	0.94 [0.72; 1.22]	0.64	0.89 [0.69; 1.14]	0.36
BIGTT-AIR	0.98 [0.74; 1.30]	0.88	0.65 [0.44; 0.94]	0.02	1.22 [0.83; 1.78]	0.31
s-Cholesterol (10 mmol/L)	3.29 [0.56; 19.5]	0.19	0.97 [0.10; 10.9]	0.98	0.19 [0.02; 1.94]	0.16
s-Triglycerides (mmol/L)	0.91 [0.77; 1.08]	0.29	1.17 [0.98; 1.39]	0.08	1.01 [0.83; 1.23]	0.93
s-HDL (mmol/L)	1.13 [0.59; 2.16]	0.73	1.32 [0.54; 3.19]	0.54	0.74 [0.32; 1.72]	0.49
s-FFA (mmol/L)	0.96 [0.30; 3.08]	0.95	2.37 [0.49; 11.4]	0.28	1.06 [0.24; 4.74]	0.94
Systolic BP (10 mmHg)	1.02 [0.91; 1.14]	0.73	1.04 [0.91; 1.20]	0.56	0.92 [0.80; 1.06]	0.22

BP = blood pressure, BIGTT-S_I = OGTT-derived index of insulin sensitivity, BIGTT-AIR = OGTT-derived index of acute insulin response, FFA = free fatty acids.

¹All values for the S-49 are derived from the OGTT examination and are therefore fasting compared with non-fasting for S-46.