Figure 1. Phospho-specific epitopes are activated in RA synovial tissue lymphocytes.

Cell lysates were prepared from ST lymphocytes isolated from the affected joints of 3 patients with late-stage RA, at the time of joint replacement, as described in Methods. Lysates were analyzed by a customized BD PowerBlot and data are shown as mean±SE. Values represent the average intensity of triplicate readings except for p-JNK, p-STAT5, p-cdc2 and p-src, which are averages of duplicate samples.