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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Mol Microbiol. 2009 Jun 1;73(1):5–19. doi: 10.1111/j.1365-2958.2009.06742.x

Figure 4.

Figure 4

Model for the Red four component TCS mechanism controlling progression through the M. xanthus developmental program. Left panel: Developmental progression is repressed when RedC histidine protein kinase (HPK) phosphorylates the receiver (REC) domain of RedF, a stand-alone response regulator. Right panel: Development proceeds when RedC instead phosphorylates the first REC domain of RedD, a dual receiver response regulator. The phosphoryl group is then transferred to the HPK-like protein, RedE, and RedE acts as a phosphatase on RedF. Courtesy of Penelope Higgs.