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miRNA biosynthesis pathway. Following cleavage of the pri-miRNA by Drosha, pre-miRNA exits the nucleus and is cleaved by Dicer to a duplex. From this miRNA/miRNA* duplex, the miRNA strand is loaded into the RNA-induced silencing complex (RISC), and the miRNA* strand is destroyed. Translational repression of targeted mRNAs by RISC may occurs within the P-Body.
