Fig. 4.

Histology of female mice fed AIN93 diet from weaning. +/+, +/−, and −/− animals were euthanized at the manifestation of dermatitis in −/− (∼21weeks of age). No difference in histology was observed between +/+ and +/−. A: Ovary from +/+ mouse shows normal follicle maturation with multiple corpora lutea (arrows), whereas (B) ovary from −/− mouse is smaller and lacks mature corpora lutea. C: Thymus from +/+ mouse has normal cortex (c) and medulla (m), while (D) thymus from −/− mouse is small with severe cortical lymphocyte depletion. E: Spleen from +/+ mouse has normal white (w) and red (r) pulp. F: Spleen from −/− mouse is greatly enlarged (4.0×) due to expanded red pulp (r) whereas white pulp (w) is depleted. G: Ulcerative dermatitis (arrow) on head of −/− at necropsy. H: Ulceration of −/− skin with superficial exudation (e) and severe inflammation (i) of the dermis. H and E stain.