Fig. 5.

Histology of male mice fed AIN93 diet from weaning. +/+, +/−, and −/− animals were euthanized at the manifestation of dermatitis in −/− (∼20 weeks of age). No difference in histology was observed between +/+ and +/−. Skin from a −/− mouse, (A) unaffected area, and (B) with ulcerative dermatitis (arrows). C: Seminiferous tubules in testis from +/+ mouse shows all stages of spermatogenesis including elongated spermatids (arrows) and spermatozoa (in lumen), while (D) testis from −/− mouse shows lack of elongated spermatids and spermatozoa. E: Epididymis from +/+ mouse contains viable spermatozoa (bracket), while (F) epididymis from −/− mouse contains sloughed round spermatids (smaller cells with round nuclei) and spermatocytes (larger cells with more dispersed chromatin). G: The intestine from a −/− mouse has an ulcer (bracket) at the ileocecal junction. H: Duodenum ulcer (arrow) in −/− with inflammation extending into the submucosa. No intestinal ulceration was found in +/+ and +/− animals. H and E stain.