TABLE 1.

Multivariate analysis for the association between CETP activity, as a dependent variable, and CETP, apoCI, and triglyceride concentrations

	Rabbit Model			Human Model
Variable	Regression Coefficient	SE	P	Regression Coefficient	SE	P
CETP	69.003	17.707	0.0006	12.639	2.015	<0.0001
apoCI	0.661	0.469	0.1702	−0.380	0.081	<0.0001
TG	28.982	33.961	0.4012	1.517	2.512	0.5515
R2		0.650			0.680

The two models were built including CETP, apoCI, and triglycerides (TG). CETP mass concentration was the only significant predictor of plasma CETP activity in rabbits (n = 30), while both CETP mass and apoCI concentrations were independent predictors of plasma cholesteryl ester transfer rate in humans (n = 28). Included parameters accounted for 65% and 68% of the variation in plasma CETP activity values in the rabbit and human models, respectively.