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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Nov 14;1787(5):384–392. doi: 10.1016/j.bbabio.2008.11.003

Table 1.

Effect of different Complex I inhibitors on ROS production in SMP supplemented with 150 μM NADH

Inhibitor DCFDA Amplex Red
Rotenone (2 μM) +53%±23 +62%±3
Piericidin A (1 μM) +101%±30 +53%±5
Rolliniastatin 1 (30 μM) +17%±4
Rolliniastatin 2 (30 μM) +17%±9
Stigmatellin (60 μM) −11%±5 −34%±3
Mucidin (80 μM) −7%±6 −8%±3
Capsaicin (50 μM) −49%±3
CoQ2 (20 μM) −39%±23

The results are expressed as percent of fluorescence variation with respect to the control treated with 1.8 μM Mucidin. Fluorescence intensity was collected after 2400 s from NADH addition. Each value is the mean of at least 10 different determinations.