Table 3.

HPV18 DNA load at enrollment between patients who were initially diagnosed with CIN2–3 at enrollment and those diagnosed during follow-up who were enrolled in the immediate colposcopy or HPV triage arm^*

Cytology at enrollment	Women without CIN2–3		Women with entry CIN2–3		Women with follow-up CIN2–3		P†	P‡
	No.	Mean load (±SD)	No.	Mean load (±SD)	No.	Mean load (±SD)
All women
Overall	125	3.95 (±1.80)	46	3.59 (±1.66)	17	3.89 (±1.09)	.53	.30
Within normal limits	33	2.66 (±1.82)	2	3.51 (±0.95)	5	3.51 (±1.11)	1.00	.24
ASC-US	33	4.06 (±1.64)	16	3.61 (±2.01)	5	4.38 (±1.27)	.44	.58
LSIL	51	4.51 (±1.50)	18	3.41 (±1.61)	6	3.89 (±1.05)	.73	.003
HSIL	8	5.17 (±1.42)	10	3.91 (±1.38)	1	3.34	—	—
Women without HPV16   coinfection
Overall	110	4.01 (±1.77)	32	3.78 (±1.58)	14	4.00 (±1.15)	.71	.58
Within normal limits	29	2.88 (±1.69)	2	3.51 (±0.95)	4	3.70 (±1.18)	.86	.30
ASC-US	30	4.04 (±1.72)	11	3.91 (±1.90)	5	4.38 (±1.27)	.62	.99
LSIL	43	4.53 (±1.55)	12	3.57 (±1.45)	5	3.87 (±1.17)	.86	.02
HSIL	8	5.17 (±1.42)	7	4.01 (±1.63)	0	—	—	—

^*HPV18 DNA load was expressed as log₁₀ (HPV18 E7 copies per nanogram of cellular DNA). A category of LSIL was combined with HSIL for statistical testing. CIN2–3 = cervical intraepithelial neoplasia grades 2–3; SD = standard deviation; ASC-US = atypical squamous cells of undetermined significance; LSIL = low-grade squamous intraepithelial lesion; HSIL = high-grade squamous intraepithelial lesion; — = values missing because they were not available or not applicable; HPV = human papillomavirus.

^†Comparison of HPV18 DNA load at enrollment between CIN2–3 patients who were initially diagnosed at enrollment and those diagnosed during follow-up. P values (two-sided) were calculated using a Student t test.

^‡Comparison of HPV18 DNA load at enrollment between women with and without CIN2–3 during the 2-year study period. P values (two-sided) were calculated using a Student t test.