Table 4.

Association of per 1-unit increase in log₁₀-transformed HPV18 DNA load at enrollment with risk of concurrent or subsequent diagnoses of CIN2–3 among women who were enrolled in the immediate colposcopy or HPV triage arm^*

Cytology at enrollment	No. with CIN2–3 at enrollment/No. of subjects	RR (95% CI)	No. with follow-up CIN2–3/person-years at risk	HR (95% CI)
All women
Within normal limits or ASC-US	18/94	1.04 (0.82 to 1.32)	10/153.4	1.10 (0.74 to 1.64)
LSIL or HSIL	28/94	0.79 (0.68 to 0.92)	7/114.9	0.48 (0.21 to 1.06)
Women without HPV16 coinfection
Within normal limits or ASC-US	13/81	1.09 (0.81 to 1.48)	9/138.4	1.16 (0.75 to 1.78)
LSIL or HSIL	19/75	0.80 (0.65 to 0.99)	5/98.2	0.53 (0.22 to 1.23)

^*CIN2–3 = cervical intraepithelial neoplasia grades 2–3; RR = risk ratio (a ratio of the probability of having CIN2–3 at enrollment associated with per 1-unit increase in log₁₀-transformed HPV18 DNA load); CI = confidence interval; HR = hazard ratio; ASC-US = atypical squamous cells of undetermined significance; LSIL = low-grade squamous intraepithelial lesion; HSIL = high-grade squamous intraepithelial lesion; HPV = human papillomavirus.