FIG. 2.

White blood cell levels of nucleic acid oxidative damage in the same individuals before (baseline) and after 12-month interventions of calorie restriction or exercise. Levels of RNA (A) and DNA (B) oxidative damage are shown as means ± SE. CR, calorie restriction by 20% (n = 9); EX, exercise with 20% increase in energy expenditure (n = 9). Signs mark out significant differences from baseline using paired t-tests (*p < 0.05, ***p < 0.001). Baseline levels of RNA and DNA oxidative damage did not differ significantly between CR and EX groups.