Table 2.
Amniotic fluid analysis
| Variable | All | Groups | P value | ||
|---|---|---|---|---|---|
| MR 0 | MR 1–2 | MR 3–4 | |||
| n=87 | n=13 | n=23 | n=51 | ||
| Clinical laboratory analysis | |||||
| Glucose, mg/dL‡ | 12 [2–24] | 28 [16–40] | 23 [14–44] | 3 [2–10] | < 0.001 |
| Glucose < 10 mg/dL§ | 48 (55) | 2 (15) | 5 (23) | 41 (82) | < 0.001 |
| Glucose < 15 mg/dL§ | 39 (45) | 1 (8) | 1 (5) | 37 (74) | < 0.001 |
| LDH, U/L‡ | 266 [123–893] | 104 [26–162] | 185 [2–6470] | 811 [280–1,343] | < 0.001 |
| LDH > 419 U/L§ | 28 (37) | 1 (9) | 2 (9) | 25 (58) | < 0.001 |
| WBC, cells/mm3 | 80 [5–1,135] | 4 [2–14] | 5 [2–14] | 783 [127–2,132] | < 0.001 |
| WBC > 50 cells/mm3§ | 46 (52) | 1 (8) | 4 (17) | 41 (80) | < 0.001 |
| WBC > 100 cells/mm3§ | 41 (47) | 1 (8) | 2 (9) | 38 (75) | < 0.001 |
| RBC, cells/mm3 | 246 [19–1,045] | 250 [21–442] | 133 [7–433] | 350 [27–1,272] | 0.088 |
| Positive Gram stain § | 37 (43) | 2 (15) | 6 (26) | 29 (57) | 0.005 |
| Positive cultures § | 46 (53) | 2 (15) | 5 (22) | 39(76) | < 0.001 |
| Research laboratory analysis | |||||
| IL-6, ng/mL‡ | 7.5 [1.2–24.2] | 0.5 [0.2–0.9] | 1.5 [0.5–3.9] | 14.9 [9.0–56.6] | < 0.001 |
| IL-6 > 11.4 ng/mL§ | 31 (39) | 0 (0) | 1 (5) | 30 (65) | < 0.001 |
| MMP-8, ng/Ml‡ | 171.5 [26.1–502.8] | 7.8 [4.4–17.1] | 33.1 [8.3–49.7] | 449.2 [236.1–1,178.6] | < 0.001 |
| MMP-8 >23 ng/mL§ | 61 (76) | 3 (23) | 12 (57) | 46 (100) | < 0.001 |
‡
Data presented as median [interquartile range] and analyzed by Kruskal-Wallis ANOVA among the 3 groups.
§
Data presented as n (%) and analyzed by Chi square among the 3 groups. (mg): milligrams; (ng): nanograms; (dL): decilitre; (U): units; (L): litre; (LDH); lactate dehydrogenase; (WBC): white blood cells; (RBC): red blood cells; (IL-6): interleukin 6; (MMP-8): matrix metalloprotease 8; MR: mass restricted score.