Table 6.

Accuracy of fetal heart rate (FHR) monitoring patterns (FHR-MP) in identifying newborns diagnosed with early onset neonatal sepsis (EONS).

Variable	Sensitivity	Specificity	PPV	NPV	Accuracy
FHR baseline*
>150 beats/min. at IEV	28 [10–46]	90 [82–98]	54 [27–81]	75 [65–85]	71 [62–81]
>130 beats/min. at AEV	83 [68–98]	37 [25–50]]	35 [23–47]	85 [71–98]	51 [40–61]
>130 beats/min. at DEV	88 [76–101]	36 [24–49]	38 [26–51]	88 [74–101]	52 [42–63]
Non-reactive FHR-MP
at IEV	40 [21–59]	78 [67–89]	43 [23–64]	75 [65–86]	67 [57–77]
At AEV	36 [17–55]	66 [54–78]	31 [14–48]	28 [10–46]	57 [47–68]
At DEV	62 [43–80]	32 [20–44]	29 [17–40]	28 [10–46]	41 [31–52]
Non-reassuring FHR- MP
At IEV	32 [14–50]	95 [89–101]	73 [46–99]	77 [67–86]	76 [67–85]
At AEV	40 [21–59]	80 [69–90]	45 [25–66]	76 [65–86]	68 [58–78]
At DEV	54 [35–73]	41 [28–53]	29 [26–41]	67 [51–82]	45 [30–55]

^*cut-off values correspond to the highest accuracy (minimal false negative and false positive results) based on ROC analysis. 95% confidence intervals are given in brackets. PPV: positive predictive value; NPV: negative predictive value; (IEV): initial evaluation; (AEV): time of amniocentesis; (DEV): delivery evaluation.