Table 3.
Ventricular cross-sectional and longitudinal data
| Baseline ventricular volume (cm3) | Ventricular enlargement after six months (cm3) | Percent ventricular enlargement after six months from baseline | ||
|---|---|---|---|---|
| (mean ± SD) | (mean ± SD) | (mean ± SD) | p-value* | |
| NEC (all subjects) | 38.3 ± 19.1 | 0.6 ± 1.4 | 1.5 ± 4.3 | <0.0001 |
| MCI (all subjects) | 45.8 ± 21.4 | 1.6 ± 2.4 | 3.4 ± 6.1 | <0.0001 |
| AD (all subjects) | 49.9 ± 25.3 | 2.6 ± 2.0 | 5.7 ± 4.9 | <0.0001 |
| MCI stable | 45.6 ± 20.7 | 1.5 ± 2.3 | 3.2 ± 6.0 | = 0.0031 |
| MCI to AD progressors | 48.2 ± 29.2 | 2.8 ± 3.4 | 5.5 ± 6.1 | <0.0001 |
| NEC ε4− | 37.9 ± 18.0 | 0.6 ± 1.3 | 1.5 ± 4.0 | = 0.0102 |
| NEC ε4+ | 39.1 ± 21.8 | 0.7 ± 1.7 | 1.7 ± 5.1 | <0.0001 |
| MCI ε4− | 47.4 ± 22.6 | 1.4 ± 2.7 | 2.7 ± 6.3 | <0.0001 |
| MCI ε4+ | 44.6 ± 20.4 | 1.7 ± 2.1 | 3.9 ± 5.9 | <0.0001 |
| AD ε4− | 47.3 ± 28.0 | 1.8 ± 1.7 | 4.6 ± 4.5 | <0.0001 |
| AD ε4+ | 50.9 ± 24.2 | 3.0 ± 2.1 | 6.2 ± 5.0 | <0.0001 |
*Indicates P-values for repeated measures t-tests for two time-points (baseline and six-months).
NEC = Normal elderly control; MCI = Mild cognitive impairment; AD = Alzheimer's disease; ε4− = Subjects with no APOE ε4 allele; ε4+ = Subjects with at least one APOE ε4 allele.