Table 4.

Six-month estimated sample sizes required to detect a 20% change from the expected absolute rate of change in ventricular volumes, ADAS-cog scores, and MMSE scores

		Lateral ventricular enlargement	Δ MMSE score	Δ ADAS- Cog score
AD	Six-month	342	7056	1607
AD (ε4−)	Six-month	468	≫20 000	2100
AD (ε4+)	Six-month	257	3382	1370
MCI	Six-month	1180	7712	≫20 000

MMSE = Mini Mental State Exam; ADAS-cog = Alzheimer's disease assessment Scale–cognitive subscale; AD = Alzheimer's disease; MCI = Mild cognitive impairment.