Table 5.
Absolute baseline ventricular volumes and annual or annualized rate of lateral ventricular enlargement reported in the literature
| Study | Sample size |
Absolute ventricular volume (mean ± SD) |
Annual ventricular enlargement (mean ± SD) |
Units | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NEC | MCI | AD | NEC | MCI | AD | NEC | MCI | AD | ||
| Giesel et al., 2006 | 21 | 21 | 10 | 27.7 ± 12.5 | 24.2 ± 10.1 | 48.4± 24.3 | NA | NA | NA | ml |
| Schott et al., 2005 | 38 | 19 | 31.7 ± 22.1 | NA | 52.7 ± 25.5 | 0.8 ± 1.4 | NA | 4.1 ± 2.3 | ml | |
| Ridha et al., 2008 | 52a | NA | NA | 41.1 ± 17.8 | NA | NA | 4.58 ± 3.75b | ml | ||
| Silbert et al., 2003 | 15 | 24 | NA | NA | NA | 3.3 ± 3.5 | NA | 5.5 ± 3.2 | cm3 | |
| Jack et al., 2004 | Stable = 40 Converter = 15 | Stable = 15 Converter = 26 | Slow Progressor = 32 | NA | NA | NA | Stable: 1.7 (0.9)c | Stable: 2.6 (1.3)c | Slow Progressor: 4.3 (3.3)c | % |
| Fast Progressor = 33 | Converter: 3.4 (1.6)c | Converter: 3.4 (2.8)c | Fast Progressor: 6.4 (3.7)c | |||||||
| Wang et al., 2002 | 14 | 14 | ∼30 ± NAd | ∼60 ± NAd | 0.8 ± NA | NA | 8.2 ± NA | cm3 | ||
| Current Study | 152 | 247 | 105 | 38.3 ± 19.1 | 45.8 ± 21.4 | 49.9 ± 25.3 | 1.1 ± 2.4b | 2.7 ± 4.0b | 4.6 ± 3.7b | cm3 |
NEC = Normal elderly control; MCI = Mild cognitive impairment; AD = Alzheimer's disease.
aAD placebo group. bAnnualized Value (absolute ventricular change/scan interval in years). cMedian percent change/year (Interquartile range). dEstimated ventricular volume and standard deviations.