Table 2.

Significant changes in generalized tonic–clonic seizures: lateralized analysis (n = 43)

Brain regionsa	Corrected cluster significance Pb	Cluster Volume, kc	Location of most significant voxel	x, y, zd	Z-scoree
Pre-generalization
Hyperperfusion
Ipsilateral anterior temporal	0.011	2858	Ipsilateral anterior temporal	48, 12, −28	4.12
Hypoperfusion
Bilateral anterior cingulate, bilateral medial         anterior frontal	0.003	3650	Midline cingulate	0, 4, 46	4.00
Generalization
Hyperperfusion
Bilateral superior cerebellum	0.017	2838	Contralateral superior cerebellum	−16, −48, −16	4.03
Hypoperfusion
Bilateral anterior medial frontal, bilateral         orbitofrontal	0.006	3613	Contralateral oribital frontal	−8, 20, −20	3.70
Post-ictal
Hyperperfusion
Bilateral cerebellum, midbrain, ipsilateral         caudate, ipsilateral white matter	<0.001	19 179	Ipsilateral cerebellum	26, −52, −16	6.21
Hypoperfusion
Bilateral orbitofrontal, contralateral middle         frontal gyrus, bilateral cingulate, bilateral         precuneus, contralateral lateral parietal	<0.001	19 610	Midline anterior cingulate	2, 34, 28	5.23

Same data as in Fig. 3 and 4.

a Location of clusters with voxel-level significance P < 0.01, extent k > 125 and corrected cluster-level significance P < 0.05.

b P = cluster-level significance corrected for multiple comparisons for the entire brain.

c k = cluster size in voxels (voxel size = 2 × 2 × 2 mm).

d x, y, z are coordinates in MNI space of the most significant voxel (maximum Z-score) for the cluster.

e Z_E score for most significant voxel in the cluster.