Figure 7.

Exon array analysis identifies RTN4/Nogo as a major target of PTBP1 splicing regulation. Comparative genome-wide exon expression analyses in U251 glioma cell. Differential Expression (DE) values are plotted against Alternative Splicing Scores (AS Score) for a defined set of 20 158 RefSeq entries. The plot shows the average of three independent experiments for U251 glioma cells in which PTBP1 exon 2 splicing was changed using targeted antisense oligonucleotide-treatment. The positions of 6 RefSeq entries representing PTBP1, PTBP2 and RTN4 are indicated. P-values are provided for transcripts with significant AS scores.