Table 3.

FDG-PET—comparisons of FTLD subgroups

Hemisphere	Area	x	y	z	Brodmann Area	Cluster size	T-score
Analysis 1: FTLD Pat. with R sup aTL lesion < NCa
R	Anterior superior temporal sulcus	54	9	−24	21/22	1358	5.19
L	Anterior middle/inferior temporal gyrus	−51	3	−36	21	20	4.19
Analysis 2: FTLD Pat. with social concept selective impairment < NCb
L&R	Dorsomedial prefrontal cortex	−12	39	45	8/9	409	5.16
R	Lateral orbitofrontal/anterior superior temporal cortex	48	21	−9	47/38	246	4.26
L	Anterior superior temporal gyrus	−30	18	−36	38	37	4.03
Analysis 3: Analysis 1 inclusively masked by Analysis 2
R	Anterior superior temporal gyrus	51	9	−3	22/38	94	4.67

FDG-PET analyses using SPM5. Only areas exceeding a voxel level threshold of P = 0.005 uncorrected, five voxels and FWE- or cluster-corrected P = 0.05 over the bilateral apriori aTL ROI or the whole brain are reported.

^aOnly regions reported that also show more hypometabolism in FTLD Pat with R sup aTL lesion versus FTLD Pat. without R sup aTL lesion (inclusive mask at P = 0.005) and do not show significant hypometabolism in FTLD Pat. with no R sup aTL lesion versus Normal controls (exclusive mask at P = 0.005). ^bOnly regions reported which are also more hypometabolic in FTLD patients with social concept selective impairments than in those with the reverse dissociation (i.e. animal function concept selective impairments, inclusive mask at P = 0.05) and in which there was no significant hypometabolism for the animal function concept selective impairment group versus Normal controls (exclusive mask at P = 0.005). Analysis 3 (P = 0.005) was conducted by inclusively masking Analysis 1 at P = 0.005 for all component masks with Analysis 2 at P = 0.05 for all component masks. Inclusive masking was performed by using the Wake Forest Pickatlas ROI tool (Maldjian et al., 2003).