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. Author manuscript; available in PMC: 2009 Aug 11.
Published in final edited form as: Immunol Rev. 2008 Dec;226:205–218. doi: 10.1111/j.1600-065X.2008.00706.x

Fig. 2. The IL-10 receptor and a simplified version of signaling from this receptor.

Fig. 2

The functional receptor complex is composed of two subunits each of IL-10 R1 and IL-10R2. The Janus tyrosine kinases JAK1 and Tyk2 associate with the cytoplasmic tails of the receptor and phosphorylate tyrosine residues in IL-10R1, to which STAT3 is recruited. STAT3 homodimers translocate into the nucleus and bind to STAT elements in several immune response genes, including IL-10 itself and the SOCS genes.