| Regulators of virulence factors |
| AgrA |
Staphylococcus aureus, other gram-positive bacteria |
Wound infection, toxic shock syndrome |
Production of exotoxins, hemolysins, staphylokinase, other secreted proteins |
| AlgR |
Pseudomonas aeruginosa |
Cystic fibrosis |
Biosynthesis of extracellular polysaccharide alginate; twitching motility |
| VirR |
Clostridium perfringens, C. tetani, C. botulinum |
Gas gangrene |
Production of exotoxins, collagenase, hemagglutinin |
| FasA |
Streptococcus pyogenes |
Pharyngitis, tonsillitis, necrotizing fasciitis |
Expression of fibronectin-binding adhesin, streptokinase, streptolysin S |
| MrkE |
Klebsiella pneumoniae, other enterobacteria |
Pneumonia, urinary tract infections |
Expression of type 3 fimbriae |
| Regulators of housekeeping functions |
| ComE |
Streptococcus pneumoniae, other streptococci |
Middle ear infection, pneumonia, meningitis |
Competence to DNA transformation |
| LytT, LytR |
Bacillus anthracis, Staphylococcus aureus, other gram-positive bacteria |
Antrax See above |
Peptidoglycan turnover, autolysis |
| CbaR, PlnC |
Lactobacillus plantarum, other gram-positive pacteria |
None, many strains are probiotic (beneficial) |
Production of bacteriocins (short anti-bacterial peptides) |
| CoxC |
Oligotropha carboxidovorans, other soil α-proteobacteria |
None |
Utilization of carbon monoxide, other environmental responses |
