Table 3.

Comparison of serum proteome patterns among different sub-groups of breast cancer patients.

Component m/z value	S.D.	p-value	Frequency [%]
Age (median = 56.5 years)		>median (n = 42) vs. <median (n = 42)
5353.64	11.54	0.020	48.4
2475.96	2.37	0.029	19.9
4098.35	25.90	0.032	22.5
3024.45	11.71	0.035	20.2
4070.43	5.58	0.048	19.2
T – primary tumor size		T1 (n = 44)vs. T2 (n = 40)
5353.64	11.54	0.033	21.9
2873.93	7.13	0.038	20.5
5343.98	6.26	0.051	15.8
3024.45	11.71	0.073	32.8
3249.64	5.24	0.075	12.4
N – nodal status		N0 (n = 63)vs. N1 (n = 20)
8618.25	10.83	0.024	45.1
8602.25	29.35	0.036	29.5
2909.04	10.58	0.038	32.5
8607.98	5.60	0.040	25.7
8682.92	8.83	0.047	28.2
G – histopathological grade		G1+G2 (n = 54)vs. G3 (n = 20)
2937.50	6.76	0.004	34.1
2556.63	8.07	0.007	44.1
2909.04	10.58	0.011	36.8
7547.58	12.44	0.022	37.7
4793.63	5.91	0.026	8.1
ER – estrogen receptor status		ER(-) (n = 29) vs. ER(+) (n = 51)
7915.93	29.15	0.038	42.4
6302.67	4.03	0.039	23.6
8246.58	14.13	0.043	27.5
2599.96	3.93	0.044	28.9
3367.65	13.43	0.061	22.4
PR – progesterone receptor status		ER(-) (n = 32) vs. ER(+) (n = 49)
7101.57	8.39	0.002	50.7
9965.62	16.77	0.014	37.3
7750.49	24.72	0.015	30.6
3367.65	13.43	0.018	30.5
9934.38	23.21	0.020	28.3

The five spectral components with the lowest p-values were selected for each comparison. Shown are spectral components (m/z values), S.Ds. of the corresponding model Gaussians, and their relative frequencies in classifiers. The p-values (uncorrected) are for differences measured by the Mann-Whitney U test for each individual component.