Table 3.

Characterization of 48 MULEs analyzed in this study

Clades	Analyzed sequences	Conserved motifs
		All clades	Dispersed	Clade-specific
IS256	8	1a, 4 and 8c	-	5d and 9d
MuDR	12	1a, 4 and 8b	7e and 10f	-
Hop/Jittery	12	1a, 4 and 8b	7e and 10f	11f
EMULEs	10	1a, 4 and 8	-	2f, 3f and 6f
TvCaMULEs	6	1a, 4 and 8	10f	12f
TOTAL	48	12

^a 25-aa signature sequence described by Eisen et al. [19];

Active site residues found into motifs 4 and 8: ^bD34E and ^cD38-40E;

Motif similar to Mutator-like transposase domain corresponding to: ^d pfam00872 and ^e pfam03108;

^f No match between motif and putative conserved domains have been detected.