FIG. 2.
FMT-PET uptake (Ki) in the putamen. (A) Mean FMT uptake in fully lesioned (right) and partially lesioned (left) putamen at baseline and post-treatment for GDNF-treated (solid columns) and PBS control monkeys (shaded columns). GDNF-treated monkeys showed significant bilateral increases in Ki values at 6 months compared with baseline (paired t test, *p < 0.05), whereas control monkeys did not show a significant change. FMT-PET uptake in both hemispheres was also significantly greater at 6 months in the AAV2-GDNF monkeys compared with the controls (unpaired t test, **p < 0.01). (B) Percentage increase in FMT-PET uptake 6 months after treatment compared with the baseline PET scans was greater in the partially lesioned right putamen. Error bars indicate the SEM.