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. 2009 Apr 1;20(5):511–518. doi: 10.1089/hum.2008.201

FIG. 5.

FIG. 5.

Enhanced expression of tyrosine hydroxylase (TH) after AAV2-GDNF delivery. Immunostaining for TH demonstrated almost complete destruction of TH-positive fibers in the fully MPTP lesioned (right) caudate–putamen compared with the partially lesioned (left) hemisphere. Twelve months after bilateral AAV2-GDNF delivery (A), and the subsequent upregulation of GDNF in the putamen (A, middle), TH expression in both hemispheres was enhanced relative to PBS-treated controls (B). Very intense TH staining was observed in the left putamen of AAV2-GDNF-treated monkeys (left) with no evident sign of MPTP-induced lesioning. Within the right putamen of AAV2-GDNF-treated monkeys, we observed upregulation of TH, particularly in the medial–ventral region (right). TH staining in the right putamen of PBS controls was restricted to a limited number of TH-positive fibers with none of the diffuse TH staining seen in either the left putamen or AAV2-GDNF-treated monkeys.