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. Author manuscript; available in PMC: 2010 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2009 Jul 9;17(16):5887–5893. doi: 10.1016/j.bmc.2009.07.008

Scheme 1.

Scheme 1

Synthesis of the 6-O-DPC-2-N-methylguanosine 5: (i) acetic anhydride, DMAP, Et3N, acetonitrile, 0.5 h; (ii) p-thiocresol, acetic acid, formaldehyde, ethanol, reflux; (iii) NaBH4, DMSO, 100 °C; (iv) DPCCl, diisopropylethylamine, pyridine; (v) a) 2 M NaOH, 20 min; b) acetic acid.