Table 3.
Nonword-Repetition Group Means for CMIP and ATP2C2 Risk Variants
| Genotype (Number of Risk Alleles) | Single SNP | rs6564903 (CMIP) |
|||
|---|---|---|---|---|---|
| TT (0) | CT (1) | CC (2) | |||
| Single SNP | 96.62 | 92.57 | 86.30 | ||
| rs11860694 (ATP2C2) | GG (0) | 96.54 | 99.14 | 99.85 | 89.65 |
| CG (1) | 91.77 | 99.40 | 93.10 | 85.84 | |
| CC (2) | 87.03 | 88.44 | 88.33 | 83.32 | |
The effects of CMIP (rs6564903) and ATP2C2 (rs11860694) on nonword-repetition performance were modeled as additive effects within a regression framework in the R package. This regression model included all available SLIC children with genotype and nonword-repetition data (n = 503). Group means were calculated for each SNP in isolation (“Single SNP” entries) and in combinations of genotypes (3 × 3 grid) across risk SNPs. Note that individuals carrying combinations of risk alleles performed significantly worse than those carrying risk variants at a single locus. Nonword-repetition scores are age adjusted and standardized against normal population controls with a mean of 100 and a SD of 15.