Table 4.

 Suicidality risk for active drug relative to placebo (ideation or worse) in all adults by indication

Indication category	Drug			Placebo		Odds ratio (95% CI), P value	Risk difference/1000 (95% CI), P value
	Events	Participants		Events	Participants
All indications	326	63 327		204	35 904	0.85 (0.71 to 1.02), 0.08	−0.87 (−1.89 to 0.15), 0.10
Psychiatric indications:
All	314	50 043		197	27 164	0.83 (0.69 to 1.00), 0.05	−1.28 (−2.57 to 0.00), 0.05
Major depression	218	30 485		123	14 728	0.85 (0.67 to 1.07), 0.16	−1.42 (−3.23 to 0.40), 0.12
Other depression	13	2744		9	1863	0.90 (0.38 to 2.14), 0.81	−0.15 (−4.40 to 4.11), 0.95
Other	83	16 814		65	10 573	0.79 (0.56 to 1.11), 0.17	−1.37 (−3.33 to 0.59), 0.17
Non-psychiatric indications	12	13 284		7	8740	1.47 (0.57 to 3.79), 0.42	0.28 (−0.50 to 1.05), 0.48
Behavioural indications	6	8144		3	5218	1.43 (0.35 to 5.86), 0.62	0.16 (−0.72 to 1.03), 0.72
Other indications	6	5140		4	3522	1.51 (0.42 to 5.40), 0.53	0.38 (−0.96 to 1.73), 0.58