Table 9.
Suicidality risk for active drug relative to placebo by age and diagnostic category
| Diagnostic category | Age <25 | Age 25-64 | Age ≥65 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | P value | Estimate (95% CI) | P value | Estimate (95% CI) | P value | ||||
| Odds ratio | |||||||||
| Ideation or worse: | |||||||||
| Major depressive disorder | 1.46 (0.70 to 3.07) | 0.31 | 0.89 (0.68 to 1.16) | 0.38 | 0.38 (0.19 to 0.79) | 0.01 | |||
| Other depression | 1.10 (0.18 to 6.56) | 0.92 | 0.84 (0.31 to 2.30) | 0.74 | No events | — | |||
| Other psychiatric disorders | 1.92 (0.88 to 4.20) | 0.10 | 0.61 (0.41 to 0.89) | 0.01 | One event | — | |||
| Ideation alone: | |||||||||
| Major depressive disorder | 1.56 (0.56 to 4.35) | 0.40 | 0.74 (0.54 to 1.01) | 0.06 | 0.56 (0.26 to 1.24) | 0.15 | |||
| Other depression | One event | — | 1.06 (0.34 to 3.30) | 0.92 | No events | — | |||
| Other psychiatric disorders | 1.07 (0.40 to 2.81) | 0.90 | 0.64 (0.41 to 0.99) | 0.04 | One event | — | |||
| Preparation or worse: | |||||||||
| Major depressive disorder | 1.36 (0.47 to 3.96) | 0.40 | 1.41 (0.83 to 2.38) | 0.20 | 0.06 (0.01 to 0.58) | 0.01 | |||
| Other depression | 2.07 (0.22 to 19.5) | 0.52 | 0.32 (0.03 to 3.56) | 0.35 | No events | — | |||
| Other psychiatric disorders | 4.82 (1.08 to 21.4) | 0.04 | 0.51 (0.22 to 1.18) | 0.11 | No events | — | |||
| Risk difference/1000 participants | |||||||||
| Ideation or worse: | |||||||||
| Major depressive disorder | 4.53 (−2.76 to 11.8) | 0.22 | −1.00 (−2.95 to 0.95) | 0.32 | −7.32 (−12.6 to −2.04) | 0.01 | |||
| Other depression | 5.00 (−37.2 to 47.2) | 0.82 | −0.51 (−4.32 to 3.30) | 0.79 | No events | — | |||
| Other psychiatric disorders | 5.73 (−0.30 to 11.8) | 0.06 | −2.51 (−4.59 to −0.42) | 0.02 | −3.84 (−8.81 to 1.13) | 0.13 | |||
| Ideation alone: | |||||||||
| Major depressive disorder | 3.49 (−1.95 to 8.94) | 0.21 | −1.61 (−3.28 to 0.06) | 0.06 | −3.71 (−7.91 to 0.50) | 0.08 | |||
| Other depression | −11.5 (−29.4 to 6.42) | 0.21 | 0.25 (−3.09 to 3.58) | 0.88 | No events | — | |||
| Other psychiatric disorders | 0.79 (−4.00 to 5.58) | 0.75 | −1.82 (−3.67 to 0.03) | 0.05 | −3.84 (−8.81 to 1.13) | 0.13 | |||
| Preparation or worse: | |||||||||
| Major depressive disorder | 0.91 (−4.09 to 5.92) | 0.72 | 0.60 (−0.41 to 1.60) | 0.24 | −3.41 (−6.25 to −0.57) | 0.02 | |||
| Other depression | 19.1 (−17.0 to 55.2) | 0.30 | −0.76 (−2.51 to 1.00) | 0.40 | No events | — | |||
| Other psychiatric disorders | 5.11 (1.31 to 8.91) | 0.01 | −0.59 (−1.50 to 0.32) | 0.20 | No events | — | |||