Figure 5. Reproducibility of input-Seq coverage patterns across different strains and experiments.

Scatter plots, comparing position-by-position across the genome the sequence read densities between different experiments. A. Comparison of input-Seq read counts between two distinct but nearly-isogenic S. cerevisiae/S. bayanus hybrid diploid strains. The samples were prepared in parallel in the same laboratory, as described in the Materials & Methods. B. Comparison of input-Seq read counts between samples from S. cerevisiae and S. cerevisiae/S. bayanus hybrid, prepared in different laboratories. C. Comparison of genomic sequence read counts to input-Seq read counts (S. bayanus/S. cerevisiae hybrid comparison in the left panel, and S. cerevisiae input-Seq comparison in the right panel).