Table 2.
The association between SNPs in immune regulatory and DNA repair pathways and stomach cancer
| Gene | SNP* | MAF† | Genotype | N | Frequency | Crude | Adjusted§ | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Cases | OR | 95% CI | P value‡ | OR | 95% CI | P value | |||||
| PTGS2 | rs5277 | 0.04 | GG | 494 | 0.92 | 0.97 | 1.00 | 1.00 | ||||
| GC | 32 | 0.07 | 0.03 | 0.44 | (0.18, 1.08) | 0.073 | 0.42 | (0.13, 1.28) | 0.127 | |||
| CC | 2 | 0.01 | 0.00 | |||||||||
| PTGS2 | rs5278 | 0.01 | TT | 522 | 0.98 | 0.98 | 1.00 | 1.00 | ||||
| TC | 11 | 0.02 | 0.02 | 1.15 | (0.33, 3.99) | 0.822 | 2.27 | (0.53, 9.69) | 0.270 | |||
| PTGS2 | Rs5279 | 0.05 | TT | 525 | 0.91 | 0.97 | 1.00 | 1.00 | ||||
| TC | 42 | 0.09 | 0.03 | 0.33 | (0.14, 0.79) | 0.013 | 0.24 | (0.08, 0.73) | 0.012 | |||
| PTGS2 | Rs689470 | 0.01 | CC | 489 | 0.99 | 0.97 | 1.00 | 1.00 | ||||
| CT | 8 | 0.01 | 0.03 | 3.33 | (0.79, 14.12) | 0.102 | 7.49 | (1.21, 46.20) | 0.030 | |||
| TNFA | rs1799964 | 0.20 | TT | 339 | 0.63 | 0.70 | 1.00 | 1.00 | ||||
| TC | 154 | 0.31 | 0.28 | 0.80 | (0.54, 1.20) | 0.284 | 0.90 | (0.56, 1.46) | 0.679 | |||
| CC | 26 | 0.06 | 0.02 | 0.30 | (0.10, 0.90) | 0.032 | 0.46 | (0.14, 1.53) | 0.205 | |||
| 0.030 | 0.278 | |||||||||||
| TNFA | rs1800629 | 0.07 | GG | 448 | 0.86 | 0.84 | 1.00 | 1.00 | ||||
| GA | 74 | 0.13 | 0.16 | 1.23 | (0.74, 2.04) | 0.422 | 1.17 | (0.64, 2.17) | 0.608 | |||
| AA | 1 | 0.01 | 0.00 | |||||||||
| ERCC5 | rs1047768 | 0.28 | TT | 286 | 0.49 | 0.57 | 1.00 | 1.00 | ||||
| TC | 229 | 0.44 | 0.36 | 0.69 | (0.48, 1.01) | 0.056 | 0.65 | (0.41, 1.03) | 0.066 | |||
| CC | 41 | 0.07 | 0.07 | 0.81 | (0.40, 1.64) | 0.561 | 0.63 | (0.27, 1.51) | 0.305 | |||
| 0.121 | 0.069 | |||||||||||
| ERCC5 | rs2227869 | 0.07 | GG | 488 | 0.84 | 0.93 | 1.00 | 1.00 | ||||
| GC | 69 | 0.15 | 0.07 | 0.41 | (0.22, 0.79) | 0.008 | 0.30 | (0.13, 0.67) | 0.003 | |||
| CC | 3 | 0.01 | 0.00 | |||||||||
| ERCC5 | rs17655 | 0.50 | CC | 128 | 0.25 | 0.21 | 1.00 | 1.00 | ||||
| CG | 285 | 0.50 | 0.58 | 1.35 | (0.85, 2.14) | 0.201 | 1.53 | (0.88, 2.65) | 0.132 | |||
| GG | 130 | 0.25 | 0.21 | 0.98 | (0.57, 1.69) | 0.939 | 1.01 | (0.53, 1.94) | 0.972 | |||
| 0.934 | 0.990 | |||||||||||
| RAD51 | rs3092981 | 0.13 | CC | 382 | 0.76 | 0.72 | 1.00 | 1.00 | ||||
| CT | 125 | 0.23 | 0.28 | 1.30 | (0.84, 2.01) | 0.234 | 1.21 | (0.73, 2.01) | 0.468 | |||
| TT | 3 | 0.01 | 0.00 | |||||||||
| RAD51 | rs12593359 | 0.19 | GG | 357 | 0.64 | 0.68 | 1.00 | 1.00 | ||||
| GT | 171 | 0.32 | 0.30 | 0.86 | (0.58, 1.28) | 0.462 | 0.68 | (0.43, 1.09) | 0.108 | |||
| TT | 19 | 0.04 | 0.02 | 0.53 | (0.17, 1.62) | 0.264 | 0.67 | (0.19, 2.34) | 0.535 | |||
| 0.231 | 0.114 | |||||||||||
| RAD52 | rs2887532 | 0.07 | CC | 444 | 0.87 | 0.83 | 1.00 | 1.00 | ||||
| CT | 69 | 0.12 | 0.16 | 1.35 | (0.80, 2.27) | 0.255 | 1.33 | (0.70, 2.49) | 0.382 | |||
| TT | 4 | 0.01 | 0.01 | 1.98 | (0.28, 14.19) | 0.497 | 2.39 | (0.10, 56.48) | 0.588 | |||
| 0.193 | 0.318 | |||||||||||
| RAD52 | rs10849594 | 0.14 | TT | 405 | 0.72 | 0.76 | 1.00 | 1.00 | ||||
| TC | 135 | 0.26 | 0.22 | 0.83 | (0.54, 1.27) | 0.394 | 0.80 | (0.48, 1.33) | 0.383 | |||
| CC | 11 | 0.02 | 0.02 | 1.17 | (0.34, 4.06) | 0.806 | 1.09 | (0.22, 5.42) | 0.916 | |||
| 0.560 | 0.494 | |||||||||||
| LIG3 | rs1052536 | 0.30 | CC | 258 | 0.47 | 0.59 | 1.00 | 1.00 | ||||
| CT | 184 | 0.40 | 0.31 | 0.61 | (0.41, 0.91) | 0.016 | 0.66 | (0.41, 1.05) | 0.081 | |||
| TT | 59 | 0.13 | 0.10 | 0.68 | (0.37, 1.24) | 0.21 | 0.54 | (0.26, 1.14) | 0.108 | |||
| 0.037 | 0.040 | |||||||||||
| REV3L | rs3218599 | 0.03 | GG | 544 | 0.92 | 0.98 | 1.00 | 1.00 | ||||
| GC | 32 | 0.07 | 0.02 | 0.27 | (0.10, 0.80) | 0.017 | 0.28 | (0.08, 0.91) | 0.035 | |||
| CC | 1 | 0.01 | 0.00 | |||||||||
*
National Center for Bioinformatics (NCBI) reference sequence number
†
MAF, minor allele frequency
‡
Italicized figures represent P values for trend
§
ORs are adjusted for sex, age, body mass index, education, cigarette smoking, alcohol drinking, very hot foods eating habits, H. pylori CagA status, and green tea drinking