Table 3.

The association between haplotypes in immune regulatory and DNA repair pathways and stomach cancer

Gene	Haplotype*	Frequencies		Crude			Adjusted†
		Controls	Cases	OR	95% CI	P value	OR	95% CI	P value
PTGS2	GTTC	0.93	0.96	1.00			1.00
	CTTC	0.04	0.02	0.41	(0.18, 0.95)	0.038	0.30	(0.12, 0.76)	0.011
	GTCC	0.02	0.01	0.83	(0.27, 2.56)	0.750	0.92	(0.27, 3.16)	0.894
ERCC5	TGC	0.30	0.32	1.00			1.00
	TGG	0.40	0.43	1.02	(0.73, 1.44)	0.893	1.15	(0.79, 1.66)	0.465
	CGC	0.18	0.18	0.93	(0.61, 1.42)	0.744	1.09	(0.69, 1.72)	0.706
	CCG	0.07	0.03	0.41	(0.20, 0.86)	0.018	0.45	(0.20, 1.04)	0.062
	CGG	0.04	0.04	0.93	(0.45, 1.95)	0.857	0.84	(0.36, 1.91)	0.670
RAD51	CG	0.73	0.72	1.00			1.00
	CT	0.14	0.14	1.01	(0.71, 1.44)	0.970	1.07	(0.71, 1.62)	0.731
	TG	0.06	0.11	1.98	(1.15, 3.41)	0.013	1.95	(1.02, 3.74)	0.045
	TT	0.06	0.03	0.44	(0.07, 2.84)	0.391	0.40	(0.04, 3.86)	0.430

^*Alleles in each haplotype are listed from 5' to 3' (TNFA, rs1799964 and rs1800629; PTGS2, rs5277, rs5278, rs5279, and rs689470; ERCC5, rs1047768, rs2227869, and rs17655; RAD51, rs309298 and rs12593359; RAD52, rs2887532 and rs10849594) Variant alleles are underlined

^†ORs are adjusted for sex, age, body mass index, education, cigarette smoking, alcohol drinking, very hot foods eating habits, H. pylori CagA status, and green tea drinking