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. 2009 Aug 7;4(8):e6557. doi: 10.1371/journal.pone.0006557

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Fino et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Occurrences of sdLTD and sdLTP. Post-pre sequences (for −110<Δt<0 ms) induced sdLTD and sdLTP with success rates of 42% and 37%, respectively, and pre-post sequences (for 0<Δt<+110 ms) induced sdLTD (67%) and sdLTP (22%). (B) Magnitudes of long-term synaptic efficacy changes induced by post-pre and pre-post SDDP sequences: −37.4±5.7% and +32.1±8.9% for post-pre sdLTD and sdLTP, and −36.4±4.7% and +37.4±12.3% for pre-post sdLTD and sdLTP. (C) No correlation was found when the magnitudes of long-term plasticity induced by post-pre sequences were plotted against the amplitude of post-synaptic subthreshold depolarizations evoked during SDDP protocol (r = 0.147, p>0.05). (D) Rheobase and long-term synaptic plasticity induced by post-pre sequences in MSNs were significantly correlated (r = 0.417, p<0.05).