TABLE 2.
Bovigam test performance in cattle with confirmed bovine TB presenting with positive or negative skin test responses
| Skin test status of diseased animalsa | Data set size for ROC analysisb | AUC (95% CI)c | Cutoff pointc,d | Sensitivity (%)c | Specificity (%)c |
|---|---|---|---|---|---|
| Positive (n = 107) | 981 | 0.941 (0.903-0.977) | 0.1 | 89.7 | 96.5 |
| Negative (n = 324) | 1,198 | 0.947 (0.924-0.965) | 0.1 | 91.4 | 96.5 |
| Positive and negative combined | 0.944 (0.926-0.962) | 0.1 | 90.9 | 96.5 |
Diseased animals included cattle with culture-confirmed disease and/or lesions.
Values shown are numbers of diseased animals plus numbers of disease-free animals used in this study for ROC analysis. There were 874 TB-free animals in both analyses.
Data from ROC analysis performed with culture-positive and/or lesioned animals together with disease-free cattle. AUC, area under the curve. Blood samples from cattle with confirmed TB, presenting as either skin test positive or skin test negative, were stimulated after overnight storage. Sensitivity and specificity for the two groups individually or combined are shown.
The cutoff point was defined as the PPD B OD450 minus the PPD A OD450.