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Schematic of vesicle fusion during PSM formation. The Habc domain of Sso1p on a PSM precursor vesicle interacts with PI(4,5)P2 from an incoming vesicle, enabling Spo20p and Snc1/2p access to its H3 motif for formation of the fusogenic SNAREpin while Sso2p remains in an conformationally inactive state.
