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. 2009 Jun 5;8(8):1218–1227. doi: 10.1128/EC.00367-08

FIG. 5.

FIG. 5.

The yeast yap1Δ and sod1Δ mutants are able to cause Dar disease in the C. elegans bli-3(e767) mutant. The bli-3(e767) gene encodes a dual oxidase (CeDuox1) which contains an NADPH oxidase motif that has been implicated in ROS production in phagocytes. C. elegans bli-3(e767) mutants were exposed to yap1Δ and sod1Δ mutants, and the isogenic wild type was included as a control. The Dar response was scored on day 4 and compared to that in wild-type worms that were exposed to the yeast yap1Δ and sod1Δ mutants and wild-type counterparts.