TABLE 2.
Gene mutations in 231 RIF-resistant and 198 INH-resistant Mycobacterium tuberculosis isolates using the GenoType MTBDRplus test
| Gene(s) and mutation probe(s) | Mutation(s) or codon(s) analyzed | No. (%) of isolates |
|---|---|---|
| rpoB | ||
| MUT1 | D516V | 6 (2.6) |
| MUT2A | H526Y | 23 (10) |
| MUT2B | H526D | 8 (3.5) |
| MUT3 | S531L | 146 (63.2) |
| Missing WT | 505-533 | 48 (20.8) |
| katG | ||
| MUT1 | S315T1 | 96 (48.5) |
| MUT1,2 | S315T1, S315T2 | 1 (0.5) |
| MUT2 | S315T2 | 0 (0) |
| Missing WT | 315 | 10 (5.1) |
| inhA | ||
| MUT1 | C15T | 60 (30.3) |
| MUT2 | A16G | 0 (0) |
| MUT3A | T8C | 5 (2.5) |
| MUT3B | T8A | 0 (0) |
| katG and inhA | ||
| katG MUT1, inhA MUT1 | S315T1, C15T | 19 (9.6) |
| katG MUT1, inhA MUT3A | S315T1, T8C | 2 (1.0) |
| katG MUT1, inhA MUT3B | S315T1, T8A | 3 (1.5) |
| katG MUT1, missing inhA WT | S315T1, (−15/−16/−8) | 1 (0.5) |
| Missing katG WT, inhA MUT1 | 315, C15T | 1 (0.5) |