TABLE 1.
Summary of genotyping results of 285 consecutive samples recognized as HPV DNA positive using the hc2 low-risk probe cocktail
| HPV genotype detected | No. of positive samples | Detection method(s) | Interpretation |
|---|---|---|---|
| HPV6 | 66 | HPV6/-11-specific RT-PCR (13) | Targeted HPV genotype |
| HPV11 | 6 | HPV6/-11-specific RT-PCR (13) | Targeted HPV genotype |
| HPV42 | 105 | HPV42-specific RT-PCR | Targeted HPV genotype |
| HP43 | 8 | HPV43-specific RT-PCR | Targeted HPV genotype |
| HP44/55 | 17 | HPV44/55-specific RT-PCR | Targeted HPV genotype |
| HPV40 | 4 | INNO-LiPA HPV test | Untargeted low-risk alpha-HPV genotype related to HPV43 (species 8), analytically incorrect but clinically beneficial |
| HPV74 | 13 | INNO-LiPA HPV test | Untargeted low-risk alpha-HPV genotype related to HPV6 and HPV11 (species 10), analytically incorrect but clinically beneficial |
| candHPV91 | 9 | Sequencing of GP5+/GP6+ PCR products | Untargeted low-risk alpha-HPV genotype, related to HPV43 (species 8), analytically incorrect but clinically beneficial |
| HPV61 | 2 | Linear array HPV test | Untargeted low-risk alpha-HPV genotype (species 3), analytically incorrect but clinically beneficial |
| HPV70 | 1 | INNO-LiPA HPV test | Untargeted low-risk alpha-HPV genotype (species 7), analytically incorrect but clinically beneficial |
| candHPV87 | 1 | Sequencing of GP5+/GP6+ PCR products | Untargeted low-risk alpha-HPV genotype (species 3), analytically incorrect but clinically beneficial |
| candHPV89 | 2 | Linear array HPV test | Untargeted low-risk alpha-HPV genotype (species 3), analytically incorrect but clinically beneficial |
| candHPV90 | 4 | Sequencing of GP5+/GP6+ PCR products | Untargeted low-risk alpha-HPV genotype (species 14), analytically incorrect but clinically beneficial |
| HPV16 | 5 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV18 | 3 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV31 | 2 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV45 | 1 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV52 | 1 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV59 | 1 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV68 | 2 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk alpha-HPV genotype |
| HPV51, HPV53, HPV56, HPV58, HPV66, HPV73 | 9 | INNO-LiPA HPV test and linear array HPV test | Untargeted high-risk or probably high-risk alpha-HPV genotypes found only in combination with |
| other high-risk genotypes | |||
| HPV negative | 23 | All seven genotyping methods |