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γ-radiation-induced p21Cip1 expression depends on p38 MAPK activity. RKO cells (A) and U2OS cells (B) were incubated with SB203580 or were transfected with p38α and control siRNAs before treatment with 10 Gy of γ radiation (γ-Rad). After 16 h, total cell lysates were analyzed by immunoblotting. (C) NIH 3T3 cells expressing TopBP1-ER were treated with OHT alone or together with SB203580 for the indicated times. Total cell lysates were analyzed by immunoblotting.
