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Effect of PTP1B deficiency on the AMPK pathway in BAT. (A) α1 and α2 AMPK activities. (B and C) Immunoblotting of α AMPK subunit phosphorylation on Thr172, α1 and α2 AMPK, LKB1, and β-actin protein levels. Data are normalized to β-actin. (D) ACC activity. All experiments were carried out using 3-month-old male mice on a chow diet. Data are expressed as means ± SEM; n = 6 to 8 for each genotype. *, P < 0.05 compared to results for WT mice.
