TABLE 1.
Adenine nucleotide content and AMP/ATP and ATP/ADP ratios in EDL muscle and BAT of WT and PTP1B−/− micea
| Tissue and mouse type | Adenine nucleotide content (nmol/mg protein)
|
AMP/ATP | ATP/ADP | ||
|---|---|---|---|---|---|
| AMP | ADP | ATP | |||
| EDL muscle | |||||
| WT | 0.29 ± 0.03 | 3.66 ± 0.43 | 55.61 ± 0.79 | 0.005 ± 0.001 | 17.57 ± 2.54 |
| PTP1B−/− | 0.56 ± 0.08* | 3.43 ± 0.46 | 54.71 ± 1.03 | 0.01 ± 0.001* | 19.16 ± 3 |
| BAT | |||||
| WT | 3.08 ± 0.18 | 4.99 ± 0.35 | 8.92 ± 0.88 | 0.38 ± 0.04 | 1.91 ± 0.24 |
| PTP1B−/− | 4.57 ± 0.3* | 5.75 ± 0.33 | 7.66 ± 0.3 | 0.6 ± 0.03* | 1.37 ± 0.05 |
a
Male mice on a chow diet were sacrificed in the fed state. Data are expressed as means ± SEM. n = 10 for each genotype. *, P < 0.05 compared to results for WT mice.