Figure 1.

The Histone Acetyltransferase (HAT) Protein, p300, Is Capable of Regulating Gene Expression through Transcription Factors (TFs) and Nuclear Receptors (NRs) Binding to DNA-Specific Sequences within Euchromatin

This effect is governed by K1020 and K1024 acetylation within p300’s cell cycle regulatory domain (CRD1). SIRT1, the function of which is induced by NAD⁺ produced as a byproduct of oxidative phosphorylation, serves as the master regulatory protein in this process. Ac, Acetylase; SMRT, silencing mediator of retinoid and thyroid receptor; SUMO, small ubiquitin-related modifier.